Posttransplant Diagnostics: Utilizing Biomarkers and Genomics to Optimize Immunosuppression and Reduce Complications
This activity consists of a recorded presentation from the "Essentials of Oncology, Solid Organ and Blood/Marrow Transplant Management for the Health Care Team" conference held in Scottsdale, Ariz., March 14–15, 2022.
Biomarkers have emerged as rapid and noninvasive identifiers of solid-organ-transplant injury, dysfunction, and rejection. Highly sensitive, specific, and able to indicate injury or rejection type, including antibody-mediated rejection and T cell–mediated rejection, many biomarkers are able to rapidly identify transplant organ dysfunction in early subclinical stages. In this presentation, participants will review conventional rejection-monitoring parameters and will identify current and emerging acute-rejection biomarkers. A closer look at data — regarding such biomarkers as donor-derived cell-free DNA, gene expression profiles, mRNA transcripts, immune effector pathway molecules, cell subsets and chemokines — will provide clarity about their predictive accuracy and value in rejection monitoring, as well as their ability to improve outcomes through rapid identification of transplant-organ dysfunction.
This activity is provided by OptumHealth Education.
There was no commercial support for this activity.
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This activity is designed to meet the educational needs of case managers, nurses, pharmacists, pharmacy technicians, physicians, psychologists, social workers, dietitians, and other health care professionals who are interested in how biomarkers and genomics are used to optimize immunosuppression and reduce complications posttransplant.
At the end of this educational activity, participants should be able to:
- Describe the current and conventional rejection-monitoring parameters for solid-organ-transplant dysfunction and rejection monitoring, and their utility, efficacy and limitations.
- Review current and emerging acute-rejection biomarkers and data regarding their predictive accuracy.
- Identify the value of biomarkers in the timely diagnosis of T cell-mediated and antibody-mediated rejection and early subclinical acute rejection.
John J. Friedewald, MD
Professor of Medicine and Surgery
Medical Director of Kidney and Pancreas Transplantation
Northwestern Medical Group
About the presenter
Dr. John Friedewald received his undergraduate degree in psychology from Princeton University and his MD from Columbia University College of Physicians & Surgeons. He completed his residency and fellowship training in internal medicine and nephrology at Johns Hopkins Hospital.
He now works as a transplant nephrologist in Chicago. He is professor of medicine and surgery at the Northwestern University Feinberg School of Medicine in the Division of Nephrology and the Comprehensive Transplant Center. He is the medical director of Kidney and Pancreas Transplantation at Northwestern Memorial Hospital. Dr. Friedewald is a fellow of the American Society of Nephrology, American Society of Transplantation, and the American College of Physicians.
His clinical interests include organ allocation policy and improving options for highly sensitized patients through desensitization and kidney paired donation (KPD). One of his main research interests is developing non-invasive genomic biomarkers for use in transplantation.
Elizabeth Albert, MD
Clinical Activity Manager
Eden Prairie, MN
Matthew Cooper, MD
President, UNOS Board of Directors;
Director, Kidney and Pancreas Transplantation
Medstar Georgetown Transplant Institute;
Professor of Surgery
Georgetown University School of Medicine
Rebecca Gleason, RN, CCM
Eden Prairie, MN
Alan N. Langnas, DO, FACS
Professor of Surgery
Director, Center of Transplantation
Chief, Section of Transplantation,
Department of Surgery
University of Nebraska Medical Center;
Director of Liver Transplantation
C. Fred LeMaistre, MD
Senior Vice President
Senior Vice President, Market Operations
Tina Rydland, PharmD
Disclosures of relevant financial relationships
In accordance with the Accreditation Council for Continuing Medical Education's (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, OptumHealth Education (OHE) requires all those in control of educational content to disclose their financial relationships with ineligible companies within the prior 24 months. Ineligible companies are defined by the ACCME as companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. Individuals must disclose all financial relationships, regardless of the amount, with ineligible companies and regardless of their view of the relevance of the relationship to the education. OHE ensures that the content is independent of commercial bias.
Dr. Friedewald has indicated that he is a consultant for Eurofins Transplant Genomics; is part of the speakers’ bureau for Sanofi; and receives grant/research funding from Eurofins Viracor, Hansa BioPharma, and Veloxis.
The activity planners have no financial relationships to disclose.
Method for calculating CE credit
CE credit was calculated by the complexity of content.
In support of improving patient care, OptumHealth Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the health care team.
Credit designation statements
This activity was planned by and for the health care team, and learners will receive 1.0 Interprofessional Continuing Education (IPCE) credits for learning and change.
The participant will be awarded up to 1.0 contact hour(s) of credit for attendance and completion of supplemental materials.
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.
This activity is approved for 1.0 contact hour(s) ([0.10] CEU) in states that recognize ACPE.
Attending the full program will earn 1.0 contact hour(s).
Unique Activity Number(s): JA0007123-0000-22-138-H01-P/T
OptumHealth Education designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.
The Commission for Case Manager Certification has approved this program for a maximum of 1.0 clock hour(s) for Certified Case Managers (CCM).
Completion of this RD/DTR profession-specific or IPCE activity awards CPEUs (One IPCE credit=One CPEU).
If the activity is dietetics-related but not targeted to RDs or DTRs, CPEUs may be claimed which are commensurate with participation in contact hours (One 60 minute hour=1 CPEU).
RD's and DTRs are to select activity type 102 in their Activity Log. Performance indicator selection is at the learner's discretion.
Psychologists and social workers
Participants must have attended the entire Web-based activity and completed an evaluation to receive a certificate. Partial credit is not available.
OptumHealth Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. OptumHealth Education maintains responsibility for this program. 1.0 CE hour.
As a Jointly Accredited Organization, OptumHealth Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. OptumHealth Education maintains responsibility for this course. Social workers completing this course receive 1.0 enduring continuing education credit.
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization with which they wish to obtain credit.
- 1.00 ACPE - Pharmacists
- 1.00 ACPE - Pharmacy Technicians
- 1.00 AMA - Physicians
- 1.00 ANCC - Nurses
- 1.00 APA - Psychologists
- 1.00 Attendance - General Attendance
- 1.00 CCMC - General - Case Managers
- 1.00 CDR - Dietitians
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