Predicting, Inducing and Monitoring Graft Tolerance in Kidney Transplantation
This activity consists of recorded presentations from "Essentials of Oncology, Solid Organ and Blood/Marrow Transplant Management for the Health Care Team" held virtually May 5–6, 2021.
Patients who receive a kidney transplant are committed to lifelong systemic immunosuppressive therapy, which can be associated with long-term and serious complications. Thus, achieving graft tolerance is the “Holy Grail” of kidney transplantation. Evidence suggests that hematopoietic chimerism via combined blood/marrow- and kidney transplantation may be a safe and feasible approach for inducing tolerance in kidney transplant recipients. In addition, recently identified biomarkers that can detect tolerant or nearly tolerant patients have the potential to guide decisions on minimizing or discontinuing immunosuppression. Other novel biomarkers can be used to monitor transplant patients for acute and chronic rejection, as well as predict the risk of rejection. This presentation will review emerging strategies to predict, induce and monitor graft tolerance in kidney transplantation.
This activity is provided by OptumHealth Education.
There was no commercial support for this activity.
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This activity is designed to meet the educational needs of case managers, nurses, pharmacists, pharmacy technicians, physicians, psychologists, social workers and other health care professionals who are interested in kidney transplantation.
At the end of this educational activity, participants should be able to:
- Discuss the current status of combined blood/marrow and kidney transplantation as a strategy to induce graft tolerance in kidney transplant recipients.
- Review novel biomarkers that can identify tolerant or nearly tolerant patients, monitor for acute and chronic rejection, and predict the risk of rejection.
- Identify the patients that would benefit most from a tolerance protocol as well as those that are at greatest risk for complications.
|Joseph R. Leventhal, MD, PhD|
Interim Chief of Organ Transplantation, Department of Surgery
Fowler McCormick Professor of Surgery
Professor of Surgery (Organ Transplantation)
Elizabeth Albert, MD
Clinical Activity Manager
Eden Prairie, MN
Rebecca Gleason, RN, CCM
Clinical Activity Manager
Eden Prairie, MN
Alan N. Langnas, DO, FACS
Professor of Surgery
Director, Center of Transplantation
Chief, Section of Transplantation,
Department of Surgery
University of Nebraska Medical Center;
Director of Liver Transplantation
C. Fred LeMaistre, MD
Senior Vice President, Market Operations
Tina Rydland, PharmD
Crystal Clear Rx
Crystal Wong, MD
Propoint Medical Writing
Disclosures of relevant financial relationships
In accordance with the Accreditation Council for Continuing Medical Education's (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, OptumHealth Education (OHE) requires all those in control of educational content to disclose their financial relationships with ineligible companies within the prior 24 months. Ineligible companies are defined by the ACCME as companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. Individuals must disclose all financial relationships, regardless of the amount, with ineligible companies and regardless of their view of the relevance of the relationship to the education. OHE ensures that the content is independent of commercial bias.
Dr. Leventhal indicated he has received grant/research support and serves on the advisory board for Talaris Therapeutics. He also receives grant/research support as well as stocks and other ownership interests from TRACT Therapeutics, Inc.
The activity planners have no financial relationships to disclose.
Method for calculating CE credit
CE credit was calculated by the complexity of content.
In support of improving patient care, OptumHealth Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the health care team.
Credit Designation Statements
The participant will be awarded up to 1.0 contact hour(s) of credit for attendance and completion of supplemental materials.
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.
This activity is approved for 1.0 contact hour(s) ([0.10] CEU) in states that recognize ACPE.
Attending the full program will earn 1.0 contact hour(s).
Unique Activity Number(s): JA0007123-0000-21-178-H04-P/T
OptumHealth Education designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.
The Commission for Case Manager Certification has approved this program for a maximum of 1.0 clock hour(s) for Certified Case Managers (CCM).
Psychologists and social workers
Participants must have attended the entire Web-based activity and completed an evaluation to receive a certificate. Partial credit is not available.
OptumHealth Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. OptumHealth Education maintains responsibility for this program. 1.0 CE hour.
As a Jointly Accredited Organization, OptumHealth Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. OptumHealth Education maintains responsibility for this course. Social workers completing this course receive 1.0 enduring continuing education credit.
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization with which they wish to obtain credit.
- 1.00 ACPE - Pharmacists
- 1.00 ACPE - Pharmacy Technicians
- 1.00 AMA - Physicians
- 1.00 ANCC - Nurses
- 1.00 APA - Psychologists
- 1.00 Attendance - General Attendance
- 1.00 CCMC - General - Case Managers
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