Posttransplant Diagnostics: From Traditional Monitoring to Molecular Innovations


This activity consists of a recorded presentation from the "Essentials of Oncology and Transplant Management for the Health Care Team" conference held in Scottsdale, Ariz., April 11-12, 2024.

The timely detection and management of graft rejection, a complication experienced by 10 percent of transplant recipients, is paramount for optimal patient outcomes. This session will provide participants not only with an overview of traditional diagnostic tests and indicators of graft rejection, but also with an updated summary of the innovative molecular diagnostics emerging as effective and potentially minimally invasive (i.e., urine testing) monitors of graft rejection, including cell-free DNA (cfDNA) assays, gene expression profiling and next-generation sequencing.

Provided by
This activity is provided by Optum Health Education.

Commercial support
There was no commercial support received for this activity.

Target Audience

This activity has been designed to meet the educational needs of case managers, coders, dietitians, dietetic technicians, managed care nurses, nurses, nurse practitioners, pharmacists, pharmacy technicians, PAs, physicians, psychologists, social workers, transplant coordinators and other health care professionals.

Learning Objectives

At the end of this educational activity, participants should be able to:

  • Evaluate current diagnostic techniques for monitoring posttransplant graft rejection.
  • Analyze emerging molecular tests and other diagnostic tools for graft-rejection monitoring, including cfDNA assays, gene expression profiling, next-generation sequencing and other advanced “omics” technologies.
  • Recognize considerations and challenges associated with the utilization of advanced diagnostics as part of a personalized approach to transplant medicine and identify the value of minimally invasive techniques for graft-rejection monitoring.
Activity summary
Available credit: 
  • 0.75 ACPE - Pharmacists
  • 0.75 ACPE - Pharmacy Technicians
  • 0.75 AMA - Physicians
  • 0.75 ANCC - Nurses
  • 0.75 APA - Psychologists
  • 0.75 Attendance - General Attendance
  • 0.75 CDR - Dietitians
  • 0.75 ASWB - Social Workers
Activity opens: 
Activity expires: 

Satish Nadig, MD, PhD, FACS
Edward G. Elcock Professor of Surgery
Professor Microbiology/Immunology, & Pediatrics
Chief, Division of Abdominal Transplant Surgery
Director, Comprehensive Transplant Center
Northwestern Medicine


Elizabeth Albert, MD
Clinical Activity Manager
Optum Health Education

Matthew Cooper, MD
Mark B. Adams Chair in Transplant Surgery
Chief, Division of Transplant Surgery
Director, Solid Organ Transplant Service Line
Froedtert Memorial Lutheran Hospital;
Director, Solid Organ Transplantation
Children’s Wisconsin;
Tenured Professor of Surgery
Medical College of Wisconsin

Rebecca Gleason, RN, CCM
Activity Manager
Optum Health Education

Katie L. Lo Coco RN, BSN, CCTC, CCM
Clinical Operations Manager for Transplant Solutions M&R
Optum Health

C. Fred LeMaistre, MD
Senior Vice President
Senior Vice President, Market Operations
Physician-in-Chief, Hematology
Sarah Cannon

Navneet Majhail, MD, MS, FASTCT
Physician-in-Chief of Blood Cancers
Director, Sarah Cannon Transplant and Cellular Therapy Program at TriStar Centennial
Sarah Cannon Cancer Institute

Tina Rydland, PharmD
Executive Pharmacy Consultant

Disclosures of relevant financial relationships
In accordance with the Accreditation Council for Continuing Medical Education's (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, OptumHealth Education (OHE) requires all those in control of educational content to disclose their financial relationships with ineligible companies within the prior 24 months. Ineligible companies are defined by the ACCME as companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. Individuals must disclose all financial relationships, regardless of the amount, with ineligible companies and regardless of their view of the relevance of the relationship to the education. OHE ensures that the content is independent of commercial bias.

Financial Relationship Key
 A-Advisory Board
 CT-Clinical Trial
 G- Grant/Research Support or Funding
 I-Stocks and Other Ownership Interests 
 S-Speakers’ Bureau
 O-Other Financial or Material Support

Navneet Majhail: Anthem Inc (C); HCA Healthcare (I)    

Satish Nadig: Pandorum Technologies (G, I)

All relevant financial relationships have been mitigated. 

The remaining planners have no financial relationships to disclose.

Method for calculating CE credit
CE credit was calculated by the complexity of content.

Accreditation statement
Joint Provider LogoIn support of improving patient care, this activity has been planned and implemented by Optum Health Education. Optum Health Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit designation statements

IPCE LogoThis activity was planned by and for the health care team, and learners will receive 0.75 Interprofessional Continuing Education (IPCE) credits for learning and change.


Optum Health Education designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The American Academy of PAs (AAPA) accepts credit from organizations accredited by the ACCME.

Pharmacists/Pharmacy technicians
This activity is approved for 0.75 contact hours (0.075 CEUs) in states that recognize ACPE.
Attending the full program will earn 0.75 contact hours (0.075 CEUs).
Unique activity number: JA0007123-0000-24-049-H01-P/T

The participant will be awarded up to 0.75 contact hours of credit for attendance and completion of supplemental materials.

Nurse practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.

Completion of this RD/DTR profession-specific or IPCE activity awards CPEUs (One IPCE credit=One CPEU). 

If the activity is dietetics-related but not targeted to RDs or DTRs, CPEUs may be claimed which are commensurate with participation in contact hours (One 60 minute hour=1 CPEU). 

RD's and DTRs are to select activity type 102 in their Activity Log. Performance indicator selection is at the learner's discretion. 

Optum Health Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. Optum Health Education maintains responsibility for this program. 0.75 CE hours.

Social workers
ACE LogoAs a Jointly Accredited Organization, Optum Health Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. Optum Health Education maintains responsibility for this course. Social workers completing this course receive up to 0.75 enduring continuing education credits.

A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization with which they wish to obtain credit.

Available Credit

  • 0.75 ACPE - Pharmacists
  • 0.75 ACPE - Pharmacy Technicians
  • 0.75 AMA - Physicians
  • 0.75 ANCC - Nurses
  • 0.75 APA - Psychologists
  • 0.75 Attendance - General Attendance
  • 0.75 CDR - Dietitians
  • 0.75 ASWB - Social Workers
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