BMT is the accepted therapy of choice for a variety of malignant and nonmalignant diseases in children and adults. Improvements in transplantation techniques, center experience, and donor availability have enabled BMT to reach an ever-growing number of patients worldwide.

This activity will describe the different types of BMT and sources of stem cells and will explain the engraftment process, graft-vs-host disease, graft-vs-tumor, and graft-vs-leukemia effect. We will also provide an understanding of remission and chemo-sensitive disease; immunosuppression therapy and its role in blood/marrow transplantation; the significance of clinical trials; and the importance of a multidisciplinary team approach to achieve optimal outcomes in patients undergoing BMT.

Learning Objectives
At the end of this educational activity, participants should be able to

1. Define and explain the different types of blood/marrow transplants and the various sources of stem cells
2. Explain the mechanisms of rejection, infection, acute and chronic graft-vs-host disease, and other posttransplant complications
3. Provide an explanation of immunosuppression therapy and its role in blood/marrow transplantation
4. State the significance of clinical trials in BMT
5. Discuss the importance of a multidisciplinary team approach to maximize patient outcomes

Faculty Listing
C. Fred LeMaistre, MD
Vice President
Physician in Chief, Hematology and Hematopoietic Cell Transplant
Sarah Cannon Cancer Services
Nashville, Tennessee

Disclosures of Relevant Financial Relationships
In accordance with the ACCME Standards for Commercial Support^SM, OptumHealth Education requires all those involved in the development of activity content to disclose their relevant financial relationships. An individual has a relevant financial relationship if such person (or their spouse/partner) has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the activity content over which the individual has control.
OptumHealth Education ensures that the content is independent of commercial bias.

Faculty Disclosure
The faculty reported the following:
C. Fred LeMaistre, MD has indicated that she/he has no relevant financial relationships.

Activity Planners
Sarah Chart-Hart, RN
Senior Director
OptumHealth Education

Rebecca Gleason, RN, CCM
Activity Manager
OptumHealth Education

Martha L. New, BSN, RN, CCTC
Transplant Case Coordinator
Optum

Anne M. Sendaydiego, PharmD
AMS Consulting, LLC
Louisville, Kentucky

V. Silverstein, MD
Eagle Creek Medical Communications
Durham, North Carolina

Activity Planner Disclosures
Ms Chart, Ms Gleason, and Ms New have indicated that they are employees of and own stock in UnitedHealth Group.
Drs Sendaydiego and Silverstein have indicated that they have no relevant financial relationships.

Method of Participation
There are no fees for participating in or receiving credit for this activity.
For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Participants will receive a certificate upon successful completion of the activity, which includes the following:

• Completing the entire activity
• Completing the Pre- and Post-Activity Assessments, Activity Evaluation, and Application for Certificate of Credit forms

You must be logged into your account to participate in this activity. Get started by clicking “Begin” and viewing the “CE Info”; then follow the prompts at the bottom of the screen. At the end of the activity, you will be able to view, save, or print your certificate of participation. The Area of Practice you indicated in your profile corresponds with your certificate type. A complete listing of all of your activities can be found under “My Account”, “My Activities.”

Accreditation Statement
OptumHealth Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation Statements
Physicians
OptumHealth Education designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician Assistants
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.

Nurses
The participant will be awarded up to 1.50 contact hour(s) of credit for attendance and completion of supplemental materials.

Nurse Practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.

Case Managers
The Commission for Case Manager Certification has approved this program for a maximum of 1.50 clock hour(s) for Certified Case Managers (CCM). (Please reference the Transplantation: The Essentials of Solid Organ and Blood/Marrow Transplant Management when contacting CCMC to claim credit for this activity.)

Pharmacists
This activity is approved for 1.50 contact hour(s) ([0.15] CEU) in states that recognize ACPE.

Attending the full program will earn 1.50 contact hour(s). Unique Activity Number(s): 0860-0000-15-003-H01-P

Attendance
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been pre-approved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization to which you wish you apply credit.

Method for Calculating CE Credit
CE credit was calculated by the complexity of content.

Provided By
This activity is provided by OptumHealth Education.

Commercial Support
There was no commercial support received for this activity.

Hardware/Software Requirements
To view this activity you will need Internet Explorer 7.0+ or Firefox 3.0+ with Windows Media Player 9+, RealPlayer 12+, or Adobe Flash Player 9+. Be sure to disable your pop-up blocking software prior to the beginning of this activity.