Pharmacogenomics: Providing Personalized Medicine
Pharmacogenomics is an important part of precision medicine; it is the study of how a person’s genetic makeup can affect their response to a drug. Health care professionals (HCPs) can use pharmacogenomic information to help determine the most appropriate treatment for each individual. This activity will provide an overview on the clinical indications for using pharmacogenomics and explore resources for interpreting pharmacogenomics. The basic science of liver enzymes and their genetic variation will also be discussed.
This activity is jointly provided by OptumHealth Education and UnitedHealthcare.
No commercial support was received for this activity.
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This activity is designed to meet the educational needs of case managers, counselors, educators, nurses, nurse practitioners, pharmacists, pharmacy technicians, PAs, physicians, psychologists, social workers, therapists and other HCPs who have an interest in pharmacogenomics.
At the end of this educational activity, participants should be able to:
- Explain the basic science of liver enzymes and their genetic variations.
- Name the various liver enzymes most frequently tested in relation to psychiatric drugs.
- Describe the clinical indications for using pharmacogenomics.
- Discuss resources for interpreting pharmacogenomic test results.
- List the limitations of current pharmacogenomics tests.
Russ B. Altman, PhD, MD
Kenneth Fong Professor of Bioengineering, Genetics, Medicine, Biomedical Data Science and (by courtesy) Computer Science
About the presenter
Russ B. Altman, PhD, MD, is board certified in Internal Medicine and in Clinical Informatics. Dr. Altman holds a BA from Harvard College, an MD from Stanford Medical School, and a PhD in Medical Information Sciences from Stanford. He received the U.S. Presidential Early Career Award for Scientists and Engineers and a National Science Foundation CAREER Award. He is a fellow of the American College of Physicians (ACP), the American College of Medical Informatics (ACMI), the American Institute of Medical and Biological Engineering (AIMBE) and the American Association for the Advancement of Science (AAAS). He is a member of the National Academy of Medicine (formerly the Institute of Medicine [IOM]). He is a past president, founding board member, and a fellow of the International Society for Computational Biology (ISCB) and a past president of the American Society for Clinical Pharmacology & Therapeutics (ASCPT). He has chaired the Science Board advising the Commissioner of the U.S. Food and Drug Administration (FDA), served on the NIH Director’s Advisory Committee and co-chaired the IOM Drug Forum.
Dr. Altman’s primary research interests are in the application of computing and informatics technologies to problems relevant to medicine. He is particularly interested in methods for understanding drug action at molecular, cellular, organism and population levels. His lab studies how human genetic variation impacts drug response. His other work focuses on the analysis of biological molecules to understand the actions, interactions and adverse events of drugs. He helps lead an FDA-supported Center of Excellence in Regulatory Science & Innovation.
Sarah Chart, RN
Eden Prairie, MN
Rebecca Gleason, RN, CCM
Eden Prairie, MN
Disclosures of relevant financial relationships
In accordance with the ACCME Standards for Commercial SupportSM, OptumHealth Education requires all those in control of activity content to disclose their relevant financial relationships. An individual has a relevant financial relationship if such person (or his/her spouse/partner) has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services relate to the activity content.
OptumHealth Education ensures that the content is independent of commercial bias.
Ms. Chart and Ms. Gleason have indicated that they are employees of and own stock in UnitedHealth Group.
Russ B. Altman, PhD, MD, has indicated the following relationships:
- Advisory Board: Personalis, Inc., Cogen Therapeutics, Goldfinch Bio and Youscript
- Consultant: Personalis, Inc., Second Genome and United Health
- Stocks and Other Ownership Interests: Personalis, Inc., 23 and me and Youscript
The remaining activity faculty or planners have no financial relationships to disclose.
Method for calculating CE credit
CE credit was calculated by the complexity of content.
In support of improving patient care, this activity has been planned and implemented by OptumHealth Education and UnitedHealthcare. OptumHealth Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC), to provide continuing education for the health care team.
Credit designation statements
This activity was planned by and for the health care team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credits for learning and change.
The participant will be awarded up to 1.00 contact hour(s) of credit for attendance and completion of supplemental materials.
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.
This activity is approved for 1.00 contact hour ([0.10] CEU) in states that recognize ACPE.
Attending the full program will earn 1.00 contact hour.
Unique Activity Number(s): JA0007123-9999-20-140-H04-P/T
OptumHealth Education designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.
The Commission for Case Manager Certification has approved this program for a maximum of 1.00 clock hours for Certified Case Managers (CCM).
OptumHealth Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. OptumHealth Education maintains responsibility for this program. 1.00 CE hour.
As a Jointly Accredited Organization, OptumHealth Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. OptumHealth Education maintains responsibility for this course. Social workers completing this course receive 1.00 live continuing education credits.
Counselors and/or marriage and family therapists
CA: The Board of Behavioral Sciences has deferred CE course approvals to APA and ASWB for its licensees. See those approvals under Psychologists and Social Workers.
Other States: If your state is not specifically listed, nearly all state Counselor and MFT boards accept either APA or ASWB approval, or are reciprocal with other state licensing board approvals, such as those listed below. Check with your board to be sure.
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization from which they wish to obtain credit.
- 1.00 ACPE - Pharmacists
- 1.00 ACPE - Pharmacy Technicians
- 1.00 AMA - Physicians
- 1.00 ANCC - Nurses
- 1.00 APA - Psychologists
- 1.00 Attendance - General Attendance
- 1.00 CCMC - General - Case Managers
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