New Medications in the Management of Diabetes in Adults
Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, and a significant proportion of patients fail to achieve and maintain glycemic targets. Despite the availability of many oral antidiabetic agents, therapeutic efficacy is offset by side effects, such as weight gain and hypoglycemia. There have, however, been several recent advances that offer potentially significant quality-of-life improvements to the diabetic patient. These agents include dipeptidyl peptidase-4 (DPP-4) inhibitors that have a confined effect on lowering blood glucose and neutral effect on caloric intake; and sodium-glucose cotransporter 2 (SGLT2) inhibitors, which reduce hyperglycemia by increasing urinary glucose excretion independently of insulin secretion or action. During this session, the mechanism of action of new medications for T2DM will be explained, along with other important factors in the management of this disease.
At the end of this educational activity, participants should be able to:
- Review the mechanism of action and therapeutic utility of DPP-4 inhibitors and SGLT1 receptor agonists for the treatment of T2DM
- Explain how SGLT2 inhibitors could dramatically improve glycemic control in type 2 diabetes and how this new class of drugs may boost overall health by promoting weight loss
- Recognize why glycemic control is important in the long term to reduce the onset and severity of the complications of type 2 diabetes, as well as to reduce macrovascular risk
- List drugs that are used to aid weight loss in the management of diabetes and state the significant metabolic benefit of these medications
- Discuss the increasing focus on a personalized approach in determining the degree of blood sugar control in this patient population
Anne Peters, MD
Director, USC Westside Center for Diabetes
Director, Comprehensive Diabetes Center
Roybal Community Medical Center;
Professor of Medicine
Keck School of Medicine of USC
Beverly Hills, California
Disclosures of Relevant Financial Relationships
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Anne Peters, MD has reported the following:
Advisory Board: Abbott Diabetes Care, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb/AstraZeneca, Eli Lily Pharmaceuticals, Janssen, Merck, Novo Nordisk, Sanofi
Consultant: BD, Biodel, CVS/Caremark, Intarcia, Lexicon
Grant/Research Support: Janssen, Medtronic
Sarah Chart-Hart, RN
Rebecca Gleason, RN, CCM
Anne M. Sendaydiego, PharmD
AMS Consulting, LLC
V. Silverstein, MD
Eagle Creek Medical Communications
Durham, North Carolina
Activity Planner Disclosures
Ms Chart and Ms Gleason have indicated that they are employees of and own stock in UnitedHealth Group.
Drs Sendaydiego and Silverstein have indicated that they have no relevant financial relationships.
Method of Participation
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- Completing the entire activity
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Credit Designation Statements
OptumHealth Education designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.
The participant will be awarded up to 1.00 contact hour(s) of credit for attendance and completion of supplemental materials.
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.
This activity is approved for 1.00 contact hour(s) ([0.1] CEU) in states that recognize ACPE.
Attending the full program will earn 1.00 contact hour(s). Unique Activity Number(s): 0860-0000-15-045-H01-P
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Method for Calculating CE Credit
CE credit was calculated by the complexity of content.
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This activity is designed to meet the educational needs of nurses, pharmacists, physicians and other health care professionals who are interested in diabetes.
This activity consists of recorded presentations from the "9th Annual Medical Director Forum" held in Las Vegas, NV on November 5, 2015.
- 1.00 ACPE - Pharmacists
- 1.00 AMA - Physicians
- 1.00 ANCC - Nurses
- 1.00 Attendance - General Attendance