Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, and a significant proportion of patients fail to achieve and maintain glycemic targets. Despite the availability of many oral antidiabetic agents, therapeutic efficacy is offset by side effects, such as weight gain and hypoglycemia. There have, however, been several recent advances that offer potentially significant quality-of-life improvements to the diabetic patient. These agents include dipeptidyl peptidase-4 (DPP-4) inhibitors that have a confined effect on lowering blood glucose and neutral effect on caloric intake; and sodium-glucose cotransporter 2 (SGLT2) inhibitors, which reduce hyperglycemia by increasing urinary glucose excretion independently of insulin secretion or action. During this session, the mechanism of action of new medications for T2DM will be explained, along with other important factors in the management of this disease.

Learning Objectives
At the end of this educational activity, participants should be able to:

1. Review the mechanism of action and therapeutic utility of DPP-4 inhibitors and SGLT1 receptor agonists for the treatment of T2DM
2. Explain how SGLT2 inhibitors could dramatically improve glycemic control in type 2 diabetes and how this new class of drugs may boost overall health by promoting weight loss
3. Recognize why glycemic control is important in the long term to reduce the onset and severity of the complications of type 2 diabetes, as well as to reduce macrovascular risk
4. List drugs that are used to aid weight loss in the management of diabetes and state the significant metabolic benefit of these medications
5. Discuss the increasing focus on a personalized approach in determining the degree of blood sugar control in this patient population

Faculty Listing
Anne Peters, MD
Director, USC Westside Center for Diabetes
Director, Comprehensive Diabetes Center
Roybal Community Medical Center;
Professor of Medicine
Keck School of Medicine of USC
Beverly Hills, California

Disclosures of Relevant Financial Relationships
In accordance with the ACCME Standards for Commercial Support^SM, OptumHealth Education requires all those involved in the development of activity content to disclose their relevant financial relationships. An individual has a relevant financial relationship if such person (or their spouse/partner) has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the activity content over which the individual has control.
OptumHealth Education ensures that the content is independent of commercial bias.

Faculty Disclosure
Anne Peters, MD has reported the following:
Advisory Board: Abbott Diabetes Care, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb/AstraZeneca, Eli Lily Pharmaceuticals, Janssen, Merck, Novo Nordisk, Sanofi
Consultant: BD, Biodel, CVS/Caremark, Intarcia, Lexicon
Grant/Research Support: Janssen, Medtronic

Activity Planners
Sarah Chart-Hart, RN
Senior Director
OptumHealth Education

Rebecca Gleason, RN, CCM
Activity Manager
OptumHealth Education

Anne M. Sendaydiego, PharmD
AMS Consulting, LLC
Louisville, Kentucky

V. Silverstein, MD
Eagle Creek Medical Communications
Durham, North Carolina

Activity Planner Disclosures
Ms Chart and Ms Gleason have indicated that they are employees of and own stock in UnitedHealth Group.
Drs Sendaydiego and Silverstein have indicated that they have no relevant financial relationships.

Method of Participation
There are no fees for participating in or receiving credit for this activity.
For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Participants will receive a certificate upon successful completion of the activity, which includes the following:

• Completing the entire activity
• Completing the Pre- and Post-Activity Assessments, Activity Evaluation, and Application for Certificate of Credit forms

You must be logged into your account to participate in this activity. Get started by clicking “Begin” and viewing the “CE Info”; then follow the prompts at the bottom of the screen. At the end of the activity, you will be able to view, save, or print your certificate of participation. The Area of Practice you indicated in your profile corresponds with your certificate type. A complete listing of all of your activities can be found under “My Account”, “My Activities.”

Accreditation Statement
OptumHealth Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation Statements
Physicians
OptumHealth Education designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician Assistants
The American Academy of Physician Assistants (AAPA) accepts credit from organizations accredited by the ACCME.

Nurses
The participant will be awarded up to 1.00 contact hour(s) of credit for attendance and completion of supplemental materials.

Nurse Practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.

Pharmacists
This activity is approved for 1.00 contact hour(s) ([0.1] CEU) in states that recognize ACPE.

Attending the full program will earn 1.00 contact hour(s). Unique Activity Number(s): 0860-0000-15-045-H01-P

Attendance
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been pre-approved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization to which you wish you apply credit.

Method for Calculating CE Credit
CE credit was calculated by the complexity of content.

Provided By
This activity is provided by OptumHealth Education.

Commercial Support
There was no commercial support received for this activity.

Hardware/Software Requirements
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