CRISPR-Based Therapies for Genetic Blood Disorders

Join this session to explore updates in genetic therapy for two prevalent hemaglobinopathies: sickle cell disease and beta thalassemia. Breakthroughs in CRISPR-based interventions will be discussed, including their effectiveness, clinical implications, and results from ongoing clinical trials. The genetic mutations responsible for these conditions, along with their underlying molecular mechanisms will be examined. Participants will gain insight into the future of precision gene editing and how these discoveries will potentially redefine the landscape of treatment for hemoglobinopathies and other genetic diseases through effective and personalized patient care.

Provided by
This activity is provided by Optum Health Education.

Commercial support
There was no commercial support received for this activity.

Target Audience

This activity has been designed to meet the educational needs of dentists/allied dental staff, dietitians, dietetic technicians, nurses, nurse practitioners, pharmacists, pharmacy technicians, PAs, physicians, psychologists, social workers and other health care professionals.

Learning Objectives

At the end of this educational activity, participants should be able to:

  • Describe the underlying genetic basis of sickle cell disease and beta thalassemia, including the specific mutations that lead to these hemoglobinopathies.
  • Discuss CRISPR technology, including its mechanisms, applications in gene editing and potential for correcting genetic mutations associated with sickle cell disease and beta thalassemia.
  • Evaluate the current state of clinical research and trials involving CRISPR-based interventions for sickle cell disease and beta thalassemia and identify associated challenges, considerations, and risks.
Activity summary
Available credit: 
  • 0.75 ACPE - Pharmacists
  • 0.75 ACPE - Pharmacy Technicians
  • 0.75 ADA - CERP (Dentists/Allied Dental Staff)
  • 0.75 AMA - Physicians
  • 0.75 ANCC - Nurses
  • 0.75 APA - Psychologists
  • 0.75 Attendance - General Attendance
  • 0.75 CDR - Dietitians
  • 0.75 ASWB - Social Workers
Activity opens: 
12/15/2023
Activity expires: 
12/15/2026
Rating: 
0

Presenter
Roy Kao, MD
Assistant Professor,
Division of Hematology, Oncology and Transplantation
University of Minnesota Medical School
Minneapolis, MN

Planners
Elizabeth Albert, MD
Clinical Activity Manager
Optum Health Education

Rebecca Gleason, RN, CCM
Activity Manager
Optum Health Education

Lisa Latts, MD, MSPH, MBA, FACP
Senior Medical Director, Value-Based Care
Optum

Jennifer Malin, MD, PhD
Senior Vice President, Clinical Value
Optum Health
Chief Medical Officer
Optum Health Solutions

Tina Rydland, PharmD
Executive Pharmacy Consultant

Crystal Wong, MD
President
Propoint Medical Writing

Disclosures of relevant financial relationships
In accordance with the Accreditation Council for Continuing Medical Education's (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, OptumHealth Education (OHE) requires all those in control of educational content to disclose their financial relationships with ineligible companies within the prior 24 months. Ineligible companies are defined by the ACCME as companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. Individuals must disclose all financial relationships, regardless of the amount, with ineligible companies and regardless of their view of the relevance of the relationship to the education. OHE ensures that the content is independent of commercial bias.

Dr. Kao has disclosed grant/research support from Erditas and Vertex. 

All relevant financial relationships have been mitigated.

Method for calculating CE credit
CE credit was calculated by the complexity of content.

Accreditation statement
Joint Provider LogoIn support of improving patient care, this activity has been planned and implemented by Optum Health Education. Optum Health Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit designation statements

IPCE LogoThis activity was planned by and for the health care team, and learners will receive .75 Interprofessional Continuing Education (IPCE) credits for learning and change.

Physicians
Optum Health Education designates this enduring activity for a maximum of .75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PAs
The American Academy of PAs (AAPA) accepts credit from organizations accredited by the ACCME.

Pharmacists/Pharmacy technicians
This activity is approved for .75 contact hours (0.075 CEUs) in states that recognize ACPE.
Attending the full program will earn .75 contact hours (0.750 CEUs).
Unique activity number: JA0007123-0000-23-003-H01-P/T

Nurses
The participant will be awarded up to .75 contact hours of credit for attendance and completion of supplemental materials.

Nurse practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts credit from organizations accredited by the ACCME and ANCC.

Dentists/Allied Dental Staff

ADA Continuing Education Recognition Program Logo

Optum Health Education is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. 

Optum Health Education designates this activity for .75 continuing education credits.

Concerns or complaints about a CE provider may be directed to the provider, or to the Commission for Continuing Education Provider Recognition at ADA.org/CERP.

Dietitians 
Completion of this RD/DTR profession-specific or IPCE activity awards CPEUs (One IPCE credit=One CPEU). 

If the activity is dietetics-related but not targeted to RDs or DTRs, CPEUs may be claimed which are commensurate with participation in contact hours (One 60 minute hour=1 CPEU). 

RD's and DTRs are to select activity type 102 in their Activity Log. Performance indicator selection is at the learner's discretion. 

Psychologists
Optum Health Education is approved by the American Psychological Association (APA) to offer continuing education for psychologists. Optum Health Education maintains responsibility for this program. .75 CE hours.

Social workers
ACE LogoAs a Jointly Accredited Organization, Optum Health Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. Optum Health Education maintains responsibility for this course. Social workers completing this course receive up to .75 enduring continuing education credits.

Attendance
A certificate of attendance will be provided to learners upon completion of activity requirements, enabling participants to register with licensing boards or associations that have not been preapproved for credits. To apply for credit types not listed above, participants should use the procedure established by the specific organization with which they wish to obtain credit.

Available Credit

  • 0.75 ACPE - Pharmacists
  • 0.75 ACPE - Pharmacy Technicians
  • 0.75 ADA - CERP (Dentists/Allied Dental Staff)
  • 0.75 AMA - Physicians
  • 0.75 ANCC - Nurses
  • 0.75 APA - Psychologists
  • 0.75 Attendance - General Attendance
  • 0.75 CDR - Dietitians
  • 0.75 ASWB - Social Workers
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